Key result
Smoking cessation reduced CRP levels over time, but levels remained elevated up to 5 years post-cessation (p<0.001), with lifetime pack-years showing an independent dose relationship with CRP.
Why the study?
Does smoking cessation and lifetime smoking exposure affect C-reactive protein levels in adults without CHD?
Population
4,072 adults recruited to a Scotland-wide population health survey who did not have CHD and were not on…
Comparison
Smoking cessation and lifetime smoking exposure vs Current smokers and never-smokers
Design
Cross-sectional
Authors
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Persistent CRP elevation post-cessation may confound CV risk assessment in former smokers; hypothesis-generating for lasting inflammatory effects of smoking history.
Cross-Sectional (n=4,072)
Yes
Does smoking cessation and lifetime smoking exposure affect C-reactive protein levels in adults without CHD?
p-value: p=<.001
Lifetime smoking exposure continues to impact CRP levels post-cessation, suggesting CRP elevation is mediated by secondary mechanisms like tissue damage rather than direct cigarette smoke effects.
Hastie et al. (2008) conducted a cross-sectional in Smoking and C-reactive protein levels (n=4,072). Smoking cessation and lifetime smoking exposure vs. Never-smokers and current smokers was evaluated on C-reactive protein (CRP) levels (p=<.001). Smoking cessation reduced CRP levels over time, but levels remained elevated up to 5 years post-cessation (p<0.001), with lifetime pack-years showing an independent dose relationship with CRP.
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