Key result
Smoking cessation was associated with a lower prevalence of high C-reactive protein levels compared to current smoking (OR 0.79), though this benefit was not evident in the short-term.
Why the study?
Does smoking cessation reduce C-Reactive Protein levels in heavy smokers?
Population
3050 heavy smokers from two screening studies in Italy. Longitudinal analysis included 975 current smokers.
Comparison
Smoking cessation vs Current smoking
Design
Cohort
Follow-up
average 3.4 years
Authors
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Long-term CRP reduction after cessation may aid risk stratification in heavy smokers; leaves open short-term effects and causal cardiovascular impact.
Cohort (n=3,050)
Yes
Does smoking cessation reduce C-Reactive Protein levels in heavy smokers?
Odds Ratio: 0.79 (95% CI 0.66–0.95)
Absolute Event Rate: 35.8% vs 41.1%
Smoking cessation has a favorable long-term effect on reducing CRP levels, though this benefit is not evident in the short-term.
Gallus et al. (2018) conducted a cohort in Heavy smokers (n=3,050). Smoking cessation vs. Current smokers was evaluated on High C-Reactive Protein (≥2 mg/L) (OR 0.79, 95% CI 0.66-0.95). Smoking cessation was associated with a lower prevalence of high C-reactive protein levels compared to current smoking (OR 0.79), though this benefit was not evident in the short-term.
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