What is the clinical evidence from this study?

Study design: Other. Intervention: Interferon alpha and gamma. Primary outcome: Transcriptional induction of the GBP gene.

January 1, 1991Molecular and Cellular BiologyOpen Access

Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons.

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Key result

The promoter of the guanylate-binding protein gene contains an IFN-alpha-stimulated response element and an overlapping IFN-gamma activation site required for maximal response to IFN-gamma.

Population

Cells exposed to interferon (in vitro model)

Design

Preclinical

Authors

DLD J LewUniversity of California, San Diego TDThomas DeckerMax Perutz Labs ISInga StrehlowColumbia University

Discussion

Member takes

Implication

Advances molecular insights into interferon signaling; leaves open GBP effects on cardiovascular pathology.

Structured PICO

Population

Cells exposed to interferon (in vitro model)

Intervention

Alpha interferon (IFN-alpha) and gamma interferon (IFN-gamma)

Outcome

Transcriptional induction of the guanylate-binding protein (GBP) gene and identification of promoter response elementssurrogate

This basic science study identifies specific overlapping promoter elements required for the transcriptional induction of the GBP gene by type I and type II interferons.

Cite This Study

Lew et al. (1991) studied this question. Interferon alpha and gamma was evaluated on Transcriptional induction of the GBP gene. The promoter of the guanylate-binding protein gene contains an IFN-alpha-stimulated response element and an overlapping IFN-gamma activation site required for maximal response to IFN-gamma.

synapsesocial.com/papers/6a16bac1c23c548e2a7b85fb https://doi.org/10.1128/mcb.11.1.182

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January 1, 1991Molecular and Cellular BiologyOpen Access

Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons.

View Full Paper

Ask AI

Bookmark

Key result

The promoter of the guanylate-binding protein gene contains an IFN-alpha-stimulated response element and an overlapping IFN-gamma activation site required for maximal response to IFN-gamma.

Population

Cells exposed to interferon (in vitro model)

Design

Preclinical

Authors

DLD J LewUniversity of California, San Diego TDThomas DeckerMax Perutz Labs ISInga StrehlowColumbia University

Discussion

Member takes

Implication

Advances molecular insights into interferon signaling; leaves open GBP effects on cardiovascular pathology.

Structured PICO

Population

Cells exposed to interferon (in vitro model)

Intervention

Alpha interferon (IFN-alpha) and gamma interferon (IFN-gamma)

Outcome

Transcriptional induction of the guanylate-binding protein (GBP) gene and identification of promoter response elementssurrogate

This basic science study identifies specific overlapping promoter elements required for the transcriptional induction of the GBP gene by type I and type II interferons.

Cite This Study

synapsesocial.com/papers/6a16bac1c23c548e2a7b85fb https://doi.org/10.1128/mcb.11.1.182

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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