Key result
Long P wave duration and increased PTFV1 were greater in patients with sick sinus syndrome and correlated strongly with right atrial electrogram duration.
Why the study?
Do abnormalities in P wave morphology correlate with atrial electrophysiological parameters in patients with sick sinus syndrome?
Observational (n=54)
Do abnormalities in P wave morphology correlate with atrial electrophysiological parameters in patients with sick sinus syndrome?
Answers are grounded in this paper and cite their sources.
Long P wave duration and increased PTFV1 serve as non-invasive electrocardiographic indicators for underlying atrial electrophysiological abnormalities in patients with sick sinus syndrome.
We examined the incidence of long P wave duration in lead II and increased P terminal force in lead V1 (PTFV1), and their relationship to electrophysiological findings of atrial muscle in 34 patients with sick sinus syndrome (SSS). Patients were divided into three groups: Group I, consisting of 20 patients with various cardiac arrhythmias other than SSS and paroxysmal atrial fibrillation (PAF) who served as controls; Group II, consisting of 18 patients with SSS but without PAF; and Group III consisted of 16 patients with SSS and PAF. P wave duration was significantly longer in Group III (122 +/- 11 ms, mean +/- SD, P < 0.0001) and Group II (111 +/- 15 ms, P < 0.002) than in Group I (98 +/- 10 ms). PTFV1 was greater in Group III (0.052 +/- 0.025 ms) than in Group I (0.028 +/- 0.011 ms, P < 0.05). P wave duration and PTFV1 had significantly and/or borderline correlations with longest duration of right atrial electrograms (r = 0.84, P < 0.0001 and 0.47, P < 0.02, respectively), maximal number of fragmented deflections of atrial electrograms (r = 0.69, P < 0.0001 and r = 0.51, P < 0.02, respectively), repetitive atrial firing zone (RAFZ) (r = 0.81, P < 0.0001 and 0.48, P < 0.05, respectively) and fragmented atrial activity zone (FAAZ)(r = 0.53, P < 0.01 and r = 0.45, P = 0.06, respectively). We concluded that long P wave duration and increased PTFV1 are electrocardiographic indicators for coexistence of electrophysiological abnormalities in the atria in SSS without recognizable heart disease.
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Liu et al. (1998) conducted an observational in Sick sinus syndrome (n=54). Electrocardiographic P wave morphology (P wave duration and PTFV1) vs. Patients with various cardiac arrhythmias other than SSS and PAF was evaluated on P wave duration, PTFV1, and their correlation with electrophysiological parameters of the atrium. Long P wave duration and increased PTFV1 were greater in patients with sick sinus syndrome and correlated strongly with right atrial electrogram duration.
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