Key result
Echo planar imaging at 4.7 T demonstrated much larger changes in left ventricular volume in the working heart preparation compared to the Langendorff preparation in isolated rat hearts.
Echo planar imaging at 4.7 T can be successfully applied to isolated perfused rat hearts, demonstrating larger left ventricular volume changes in working heart versus Langendorff preparations.
May guide perfusion model selection in rodent cardiac MRI; leaves open translation to clinical imaging.
The implementation of echo planar imaging at 4.7 T is demonstrated using a homebuilt gradient and radiofrequency assembly. The application of such a technique to the study of the isolated perfused rat heart is demonstrated. Langendorff and working heart perfusion preparations are compared and changes in the left ventricular volume shown are to be much larger in the working heart preparation. Such a methodology is expected to provide a useful model for the study of cardiac function and dynamics in the normal and diseased states under controlled perfusion conditions.
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Blackband et al. (1990) studied Isolated perfused rat hearts. Echo planar imaging at 4.7 T vs. Langendorff vs working heart preparations was evaluated on Changes in left ventricular volume. Echo planar imaging at 4.7 T demonstrated much larger changes in left ventricular volume in the working heart preparation compared to the Langendorff preparation in isolated rat hearts.
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