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March 11, 2016AJP Heart and Circulatory PhysiologyOpen Access

Magnetic resonance-compatible model of isolated working heart from large animal for multimodal assessment of cardiac function, electrophysiology, and metabolism

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Population

Isolated hearts from pigs (40 kg, n = 20) and sheep (n = 1)

Comparison

Ex vivo blood perfusion in the working mode with… vs Ex vivo blood perfusion in the working mode…

Design

Preclinical

Follow-up

80 min

Authors

FVFanny VaillantUniversité de BordeauxJMJulie MagatCentre National de la Recherche ScientifiquePBPierre BourCerenis Therapeutics (France)

Discussion

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Implication

Establishes feasibility of MR-compatible isolated large-animal heart models; leaves open translation to human biventricular physiology.

Structured PICO

P
Population
Isolated hearts from pigs (40 kg, n = 20) and sheep (n = 1)
I
Intervention
Ex vivo blood perfusion in the working mode with loaded right ventricle (RV) for 80 min
C
Comparator
Ex vivo blood perfusion in the working mode without loaded right ventricle (RV) for 80 min
O
Outcome
Cardiac function assessed by left intraventricular pressure, LVEF, aortic and mitral valve dynamics, and native T1 mapping with MR imagingsurrogate

An MR-compatible isolated working large animal heart model is feasible and allows simultaneous assessment of cardiac structure, mechanics, and electrophysiology.

Cite This Study

Vaillant et al. (2016) studied this question.

synapsesocial.com/papers/6a7d562eade38b7dc346dec6https://doi.org/10.1152/ajpheart.00825.2015
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