Key result
Endocardial burst pacing-induced atrial fibrillation in goats decreased the total Cx40/Cx43 protein ratio by 50.0% in the left atrial appendage (P=0.008) and 47.8% in the right (P=0.02).
Population
Goat model of sustained atrial fibrillation
Comparison
Programmed endocardial burst pacing for 1 to 16… vs Goats in sinus rhythm (0 weeks pacing)
Design
Preclinical
Follow-up
up to 16 weeks
Authors
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Supports gap junction remodeling in goat AF; hypothesis-generating for human pathogenesis, no clinical implications yet.
p-value: p=0.008
In a goat model, sustained atrial fibrillation is associated with heterogeneous distribution and decreased content of Cx40 gap junctions, suggesting gap junctional remodeling plays a role in AF pathogenesis.
Henk van der Velden (2000) studied Atrial fibrillation. Programmed endocardial burst pacing vs. Sinus rhythm was evaluated on Cx40/Cx43 protein ratio (p=0.008). Endocardial burst pacing-induced atrial fibrillation in goats decreased the total Cx40/Cx43 protein ratio by 50.0% in the left atrial appendage (P=0.008) and 47.8% in the right (P=0.02).
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