Key result
Structural remodeling of the heart in response to injury or disease creates anatomic substrates that can enhance the risk of developing serious ventricular arrhythmias.
Design
Review
Authors
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May heighten arrhythmia vigilance in remodeled hearts; supports mechanistic understanding but leaves therapeutic targeting open.
Structural remodeling of the heart, including changes in gap junction distributions, plays a critical role in creating anatomic substrates for ventricular arrhythmias following injury.
Jeffrey E. Saffitz (1999) conducted a review in Ventricular arrhythmias and heart disease. Structural remodeling of the heart in response to injury or disease creates anatomic substrates that can enhance the risk of developing serious ventricular arrhythmias.
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