Key result
CSF enterovirus PCR was significantly more sensitive than CSF viral culture for diagnosing echovirus meningitis, detecting the virus in 81% of cases compared to 19% for culture (p<0.0001).
Why the study?
Does CSF enterovirus PCR improve diagnostic sensitivity compared to viral culture in adults with probable viral meningitis?
Population
40 adults admitted to a regional infectious disease unit with a probable diagnosis of viral meningitis…
Comparison
Cerebrospinal fluid enterovirus polymerase chain… vs Cerebrospinal fluid (CSF) virus culture
Design
Cohort
Authors
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May aid echovirus meningitis diagnosis; supports PCR superiority but leaves practice change open pending prospective data.
Observational (n=40)
No
Does CSF enterovirus PCR improve diagnostic sensitivity compared to viral culture in adults with probable viral meningitis?
Absolute Event Rate: 81% vs 19%
p-value: p=<0.0001
CSF enterovirus PCR is significantly more sensitive than viral culture for diagnosing viral meningitis, which could reduce unnecessary antibiotic use and hospital stay.
Carrol et al. (2006) conducted an observational in Echovirus meningitis (n=40). CSF enterovirus PCR vs. CSF virus culture was evaluated on Positive detection of enterovirus in CSF (p=<0.0001). CSF enterovirus PCR was significantly more sensitive than CSF viral culture for diagnosing echovirus meningitis, detecting the virus in 81% of cases compared to 19% for culture (p<0.0001).
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