Key result
Fixed-dose ACEi/CCB achieves target BP in ~70% of patients previously uncontrolled on monotherapy.
Why the study?
The study aimed to evaluate the efficacy of fixed-dose combination antihypertensives in patients with stage I and II hypertension after monotherapy failed to reduce blood pressure.
Does a fixed-dose combination of ACE inhibitors and calcium channel blockers improve blood pressure control in older patients with stage I and II hypertension previously uncontrolled on monotherapy?
Observational (n=395)
Does a fixed-dose combination of ACE inhibitors and calcium channel blockers improve blood pressure control in older patients with stage I and II hypertension previously uncontrolled on monotherapy?
Switching to a fixed-dose combination of ACE inhibitors and calcium channel blockers significantly improves blood pressure control, reduces 24-hour blood pressure oscillations, and improves lipid profiles in older hypertensive patients uncontrolled on monotherapy.
May support BP control with fixed-dose ACEI/CCB combos in stage I-II hypertension; leaves open need for RCTs in older patients.
Arterial hypertension is the condition where the blood pressure is higher than 140/90 mm Hg. Along with its complications, it is the leading factor for cardiovascular mortality. Arterial hypertension can be systolic, diastolic and combined. Diagnosis of arterial hypertension cannot be established on the basis of a single measurement, but it is necessary to make measurements in different situations and environments. The study aimed to evaluate efficacy of fixed combination antihypertensives in patients with stage I and II hypertension after antihypertensive monotherapy failed to deliver results in reducing blood pressure. In this study, we analyzed data of 395 hypertension patients aged between 65-80 years, previously treated with monotherapy. During 4 months of examination, 3 doctor visits were scheduled when their TA values were measured, and each of them received fixed-dose combination antihypertensives. The data obtained were processed by appropriate statistical analyzes.
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Nikolić et al. (2021) conducted an observational in Stage I and II hypertension (n=395). Fixed-dose combination of ACE inhibitors/Ca-antagonists vs. Baseline (previous monotherapy) was evaluated on Achievement of target blood pressure at 4 months (p=0.000). A fixed-dose combination of ACE inhibitors and calcium antagonists achieved target blood pressure in 69.8% of patients with stage I and II hypertension previously uncontrolled on monotherapy.
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