Key result
Higher machine learning-derived coronary fat attenuation index on CCTA links to adverse coronary events.
Why the study?
This study evaluated the relationship between machine learning-quantified coronary fat attenuation index on CCTA and coronary adverse events in patients with moderate or lower coronary artery stenosis.
Is coronary Fat Attenuation Index (FAI) quantified by machine learning on CCTA associated with coronary adverse events in patients with moderate or lower coronary artery stenosis?
Observational (n=172)
Is coronary Fat Attenuation Index (FAI) quantified by machine learning on CCTA associated with coronary adverse events in patients with moderate or lower coronary artery stenosis?
p-value: p=<0.001
Coronary Fat Attenuation Index (FAI) quantified by machine learning on CCTA is significantly associated with coronary adverse events in patients with less than moderate coronary artery stenosis, independent of age.
FAI by ML on CCTA was associated with events in lower-stenosis patients; hypothesis-generating for CCTA risk stratification, needs prospective validation.
Objective: This study analyzed the relationship between the coronary FAI on CCTA and coronary adverse events in patients with moderate coronary artery disease based on machine learning. Methods: A total of 172 patients with coronary artery disease with moderate or lower coronary artery stenosis were included. According to whether the patients had coronary adverse events, the patients were divided into an adverse group and a non-adverse group. The coronary FAI of patients was quantified via machine learning, and significant differences between the two groups were analyzed via t-test. Results: The age difference between the two groups was statistically significant (p < 0.001). The group that had adverse reactions was older, and there was no statistically significant difference between the two groups in terms of sex and smoking status. There was no statistical significance in the blood biochemical indexes between the two groups (p > 0.05). There was a significant difference in the FAIs between the two groups (p < 0.05), with the FAI of the defective group being greater than that of the nonperforming group. Taking the age of patients as a covariate, an analysis of covariance showed that after excluding the influence of age, the FAIs between the two groups were still significantly different (p < 0.001).
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Zhang et al. (2023) conducted an observational in Coronary artery disease with moderate or lower coronary artery stenosis (n=172). Coronary fat attenuation index (FAI) quantified by automated software on CCTA was evaluated on Coronary adverse events (p=<0.001). Coronary fat attenuation index quantified by machine learning on CCTA was significantly higher in patients with adverse coronary events compared to those without, independent of age (p < 0.001).
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