Key result
Adding vessel-specific perivascular fat attenuation index to CCTA significantly improved diagnostic accuracy for ischemia compared to CCTA alone (AUC 0.696 vs 0.607; P<0.01).
Why the study?
The association between CT-derived perivascular fat attenuation index (FAI) and lesion-specific ischemia assessed by fractional flow reserve remains unclear.
Does the addition of perivascular fat attenuation index (FAI) to CCTA improve the diagnostic accuracy for functional coronary stenosis in patients with suspected coronary artery disease?
Population
261 patients (294 vessels) assessed for CAD
Comparison
Diagnostic performance of vessel-specific FAI, lesion-specific FAI, CCTA stenosis, and combined approaches against FFR
Design
Diagnostic accuracy study
Authors
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May enhance CCTA ischemia detection in practice; hypothesis-generating and requires prospective validation before adoption.
Observational (n=261)
Does the addition of perivascular fat attenuation index (FAI) to CCTA improve the diagnostic accuracy for functional coronary stenosis in patients with suspected coronary artery disease?
Effect estimate: AUC 0.696
p-value: p=<0.01
Adding perivascular fat attenuation index (FAI) to standard CCTA significantly improves the diagnostic identification of functionally significant coronary stenosis compared to CCTA alone.
Yan et al. (2022) conducted an observational in Suspected coronary artery disease (n=261). Perivascular fat attenuation index (FAI) added to CCTA vs. CCTA alone was evaluated on Diagnostic accuracy for lesion-specific ischemia using FFR as the reference standard (AUC 0.696, p=<0.01). Adding vessel-specific perivascular fat attenuation index to CCTA significantly improved diagnostic accuracy for ischemia compared to CCTA alone (AUC 0.696 vs 0.607; P<0.01).
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