Key result
Lesions with a pericoronary fat attenuation index ≥−70.1 HU had a significantly higher prevalence of vulnerable plaques compared to those with <−70.1 HU (49.35% vs. 23.87%, P<0.001).
Why the study?
Reports were limited on whether elevated pericoronary fat attenuation index values from CCTA were associated with plaque parameters and coronary stenosis in patients with ACS.
Is elevated pericoronary fat attenuation index (FAI) associated with vulnerable plaque features and stenosis severity in patients with acute coronary syndrome?
Population
127 ACS patients with 299 lesions who underwent CCTA and CAG
Comparison
FAI-positive (FAI >=-70.1 HU) vs FAI-negative (FAI <-70.1 HU)
Design
Retrospective cross-sectional study
Authors
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Higher pericoronary FAI was associated with vulnerable plaques in ACS; leaves open prospective validation for CCTA risk stratification.
Cross-Sectional (n=127)
Is elevated pericoronary fat attenuation index (FAI) associated with vulnerable plaque features and stenosis severity in patients with acute coronary syndrome?
Absolute Event Rate: 49.35% vs 23.87%
p-value: p=<0.001
Elevated pericoronary fat attenuation index on CCTA is associated with vulnerable plaque features and greater stenosis severity in patients with ACS, highlighting its potential as an imaging biomarker for high-risk coronary artery disease.
Zhang et al. (2022) conducted a cross-sectional in Acute coronary syndrome (n=127). Pericoronary fat attenuation index (FAI) ≥−70.1 HU vs. FAI <−70.1 HU was evaluated on Prevalence of vulnerable plaques (p=<0.001). Lesions with a pericoronary fat attenuation index ≥−70.1 HU had a significantly higher prevalence of vulnerable plaques compared to those with <−70.1 HU (49.35% vs. 23.87%, P<0.001).
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