Why the study?
It was unknown whether increased pericoronary FAI on CCTA is associated with vulnerable plaque components and intracellular cytokine levels in NSTE-ACS.
Is increased pericoronary fat attenuation index (FAI) associated with vulnerable plaque components and local immune-inflammatory activation in patients with non-ST elevation acute coronary syndrome?
Population
195 lesions in 130 patients with non-ST elevation acute coronary syndrome
Comparison
Lesions with pericoronary FAI >-70.1 Hounsfield units vs lower FAI values
Design
Prospective observational study
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Should not yet change practice; leaves open FAI-guided risk stratification in NSTE-ACS pending outcome trials.
Is increased pericoronary fat attenuation index (FAI) associated with vulnerable plaque components and local immune-inflammatory activation in patients with non-ST elevation acute coronary syndrome?
Pericoronary FAI assessed by CCTA is a reliable imaging biomarker for local immune-inflammatory activation and plaque vulnerability in NSTE-ACS patients.
A 2022 study studied this question.
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