Key result
Luminal stenosis ≥50% and elevated pericoronary FAI predict higher ACS risk in stable angina.
Why the study?
Vascular inflammation affects ACS occurrence in stable angina and can be represented by FAI, prompting investigation into the prognostic value of quantitative plaque characteristics and FAI.
Does pericoronary fat attenuation index (FAI) and quantitative plaque characteristics predict acute coronary syndrome in patients with stable angina pectoris?
Observational (n=190)
Does pericoronary fat attenuation index (FAI) and quantitative plaque characteristics predict acute coronary syndrome in patients with stable angina pectoris?
Pericoronary fat attenuation index (FAI) >-88 HU and plaque lipid characteristics improve the prediction of acute coronary syndrome in patients with stable angina beyond luminal stenosis alone.
May aid ACS risk stratification in stable angina; leaves open need for prospective validation before clinical adoption.
OBJECTIVE: Vascular inflammation affects acute coronary syndrome (ACS) occurrence in patients with stable angina. Coronary inflammation can be represented by the pericoronary fat attenuation index (FAI).This study investigated the quantitative prognostic value of plaque characteristics and FAI in patients with stable angina. METHODS: Risk factors for ACS occurrence in patients with stable angina pectoris were retrospectively analyzed. The diagnostic value of FAI and plaque characteristics for ACS occurrence in these patients were determined; Kaplan-Meier curves were used to predict ACS event incidence. RESULTS: After postpropensity score matching, data of 60 and 130 patients with and without ACS, respectively, were analyzed. Pericoronary FAI, lipid volume, and lipid percentage in the narrowest segment significantly improved ACS diagnosis in patients with stable angina. Luminal stenosis ≥50% and FAI >-88 Hounsfield units (HU) were independent risk factors for ACS occurrence in patients with stable angina. Perileft anterior descending artery (LAD) FAI >-88 HU better predicted ACS occurrence in patients with stable angina than did peri-LAD FAI ≤-88 HU. CONCLUSIONS: In patients with stable angina, lipid volume and percentage and pericoronary FAI improved the diagnostic ability of luminal stenosis for ACS occurrence. Furthermore, peri-LAD FAI >-88 HU could predict ACS occurrence.
No takes yet. Share an insight, caveat, or question.
Li et al. (2025) conducted an observational in Stable angina pectoris (n=190). Pericoronary fat attenuation index (FAI) >-88 HU and luminal stenosis ≥50% vs. FAI ≤-88 HU and luminal stenosis <50% was evaluated on Acute coronary syndrome (ACS) occurrence. In patients with stable angina, luminal stenosis ≥50% and pericoronary FAI >-88 HU were independent risk factors for acute coronary syndrome occurrence.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: