Key result
Microalbuminuria was an independent predictor for the presence (OR 3.728; 95% CI 1.931-7.196; P<.001) and severity of coronary artery disease.
Why the study?
Is microalbuminuria associated with the presence and severity of coronary artery disease?
Observational (n=402)
Is microalbuminuria associated with the presence and severity of coronary artery disease?
Effect estimate: OR 3.728 (95% CI 1.931-7.196)
p-value: p=<.001
Microalbuminuria is strongly associated with the presence and angiographic severity of coronary artery disease, independent of diabetes status.
Microalbuminuria may inform CAD risk assessment; leaves open whether screening improves outcomes in prospective studies.
OBJECTIVE: To evaluate the relationship between microalbuminuria (MA) and the presence and extent of coronary artery disease (CAD). METHODS: Four hundred and two consecutive patients were divided into 4 groups based on the presence of diabetes mellitus (DM) and MA: DM(+)/MA(+), DM(+)/MA(-), DM(-)/MA(+), and DM(-)/MA(-). Severity of CAD was assessed by the Gensini scoring system. RESULTS: The Gensini score was 57 +/- 38.2 vs 16.5 +/- 19.5 (P < .001) in the DM(+)/MA(+) and DM(+)/MA(-) groups and 45 +/- 39.8 vs 9.9 +/- 16.6 (P < .001) in the DM(-)/MA(+) and DM(-)/MA(-) groups. Spearman correlation analysis demonstrated a positive relation between urine albumin/creatinine ratio (ACR) and extent of CAD both in the diabetic and nondiabetic patients (r = .584, P = .001; r = .545, P = .001). Microalbuminuria was found to be an independent predictor for the presence (OR for MA: 3.728; 95% CI, 1.931-7.196; P < .001) and severity of CAD (P < .001, beta = .563). CONCLUSION: A strong relationship between MA and the severity of CAD was reported.
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Deveci et al. (2009) conducted an observational in Coronary artery disease (n=402). Microalbuminuria vs. Absence of microalbuminuria was evaluated on Presence of coronary artery disease (OR 3.728, 95% CI 1.931-7.196, p=<.001). Microalbuminuria was an independent predictor for the presence (OR 3.728; 95% CI 1.931-7.196; P<.001) and severity of coronary artery disease.
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