Key result
Patients with type 2 diabetes and a urinary albumin-creatinine ratio ≥30 mg/g had a significantly higher SYNTAX score compared to those with a ratio <30 mg/g (P=0.02).
Why the study?
DM is a potent risk factor for CAD, and early diagnosis is crucial. Microalbuminuria indicates increased cardiovascular risk, prompting evaluation of the relation between albuminuria and CAD severity in type 2 DM.
Does the degree of albuminuria correlate with the angiographic severity of CAD in patients with type 2 DM?
Observational (n=40)
Does the degree of albuminuria correlate with the angiographic severity of CAD in patients with type 2 DM?
p-value: p=0.02
Microalbuminuria is significantly associated with more severe coronary artery disease and reduced left ventricular global longitudinal strain in patients with type 2 diabetes.
Microalbuminuria was associated with higher SYNTAX scores in type 2 DM; leaves open whether it refines CAD risk stratification.
Background Diabetes mellitus (DM) is one of the most potent risk factors for coronary artery disease (CAD). Consequently, the diagnosis of CAD in diabetic patients is very important as early as possible. Microalbuminuria is a strong and independent indicator of increased cardiovascular risk among individuals with and without diabetes. Aim The study aimed to assess the relation between the degree of albuminuria and the angiographic severity of CAD in patients with type 2 DM. Patients and methods A total of 40 patients with type 2 DM who were referred for elective coronary angiography owing to a suspected CAD were included in the study. Urinary albumin-creatinine ratio (UACR) was calculated for all patients, and the severity of CAD was assessed using the SYNTAX score. All patients were assessed by conventional and 2-D speckle tracking echocardiography. Results The study population comprised 19 (41.5%) males and 21 (58.5%) females. Their mean age was 53.5±8.7 years. Patients were classified into two groups based on the level of UACR; group 1 included patients with UACR less than 30 mg/g (19 patients), and group 2 included patients with UACR greater than or equal to 30 mg/g (21 patients). The study revealed significantly higher SYNTAX score in patients in group 2 compared with patients in group 1 ( P =0.02) and significantly lower left ventricular global longitudinal strain in patients in group 2 compared with patients in group 1 ( P =0.016). There was also a weak positive correlation between UACR and SYNTAX score and the duration of DM ( r =0.395 and 0.399, respectively). Conclusion Microalbuminuria can be used as a predictor of the presence and severity of CAD in type II DM.
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Elwafa et al. (2020) conducted an observational in Type 2 Diabetes Mellitus with suspected coronary artery disease (n=40). Urinary albumin-creatinine ratio ≥ 30 mg/g vs. Urinary albumin-creatinine ratio < 30 mg/g was evaluated on SYNTAX score (p=0.02). Patients with type 2 diabetes and a urinary albumin-creatinine ratio ≥30 mg/g had a significantly higher SYNTAX score compared to those with a ratio <30 mg/g (P=0.02).
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