Self‐reported adherence with medication and cardiovascular disease outcomes in the Second Australian National Blood Pressure Study (ANBP2)
Key result
Self-reported medication adherence in older patients with hypertension was associated with a lower risk of a first cardiovascular event compared with non-adherence (HR 0.81; 95% CI 0.67-0.98; P=0.03).
Why the study?
Does self-reported medication adherence reduce major cardiovascular events or death in older people with hypertension?
Population
4039 older people with hypertension in Australian general practice
Comparison
Self-reported adherence to medication regimen vs Non-adherence to medication regimen
Design
Cohort
Authors
Discussion
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Member takes
Implication
Supports adherence assessment in older hypertensives; leaves open whether interventions reduce events.
Study Design
Type
Cohort (n=4,039)
Multicenter
Yes
Structured PICO
Does self-reported medication adherence reduce major cardiovascular events or death in older people with hypertension?
P
Population
4039 older people with hypertension in Australian general practice
I
Intervention
Self-reported adherence to medication regimen (assessed via a four-item questionnaire)
C
Comparator
Non-adherence to medication regimen
O
Outcome
All major cardiovascular events or death; first specific cardiovascular eventcomposite
Main Result
Effect estimate: HR 0.81 (95% CI 0.67-0.98)
p-value: p=0.03
Self-reported medication adherence, particularly not forgetting to take medication, is associated with a lower risk of major cardiovascular events and death in older hypertensive patients.
Cite This Study
Nelson et al. (2006) conducted a cohort in Hypertension (n=4,039). Self-reported medication adherence vs. Non-adherence was evaluated on First cardiovascular event or a first non-fatal cardiovascular event (HR 0.81, 95% CI 0.67-0.98, p=0.03). Self-reported medication adherence in older patients with hypertension was associated with a lower risk of a first cardiovascular event compared with non-adherence (HR 0.81; 95% CI 0.67-0.98; P=0.03).