Why the study?
Does albuminuria predict a faster eGFR decline in patients with T1DM and reduced eGFR compared to normoalbuminuria?
Population
1,395 adults with Type 1 Diabetes Mellitus and eGFR ≤ 60 mL/min/1.73 m2, mean age 63, 46.9% male, from 295…
Comparison
Albuminuria (microalbuminuria or macroalbuminuria) vs Normoalbuminuria
Design
Cohort
Follow-up
4 years
Key result
Albuminuria in patients with type 1 diabetes and reduced eGFR was associated with a higher rate of >30% eGFR loss over 4 years compared to normoalbuminuria (33.6% vs 10.5%, OR 4.09).
Authors
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Normoalbuminuric kidney impairment in T1DM may progress more slowly; leaves open distinct risk stratification and targeted trials for this common phenotype.
Observational (n=1,395)
Yes
Does albuminuria predict a faster eGFR decline in patients with T1DM and reduced eGFR compared to normoalbuminuria?
Effect estimate: OR 4.09 (95% CI 2.22-7.56)
Absolute Event Rate: 33.6% vs 10.5%
p-value: p=<0.001
In patients with T1DM and reduced eGFR, normoalbuminuric kidney impairment is common (about 50%) and is associated with a significantly slower eGFR decline compared to albuminuric kidney impairment.
Lamacchia et al. (2018) conducted an observational in Type 1 diabetes mellitus with reduced GFR (n=1,395). Albuminuria vs. Normoalbuminuria was evaluated on Loss of eGFR > 30% over 4 years (OR 4.09, 95% CI 2.22-7.56, p=<0.001). Albuminuria in patients with type 1 diabetes and reduced eGFR was associated with a higher rate of >30% eGFR loss over 4 years compared to normoalbuminuria (33.6% vs 10.5%, OR 4.09).