Key result
Healthy young black subjects had significantly impaired endothelium-dependent vasodilatation compared with matched white subjects (1.76% vs 8.79%, P<0.001).
Why the study?
Does endothelium-dependent vasodilatation differ between healthy black and white subjects?
Population
52 healthy subjects (24 black and 28 well-matched white subjects)
Comparison
Ischemia induced by forearm cuff inflation and… vs Comparison between black and white subjects
Design
Cross-sectional
Authors
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Impaired endothelial function in healthy young black subjects is hypothesis-generating; leaves open causal contribution to hypertension disparities and need for longitudinal studies.
Cross-Sectional (n=52)
Does endothelium-dependent vasodilatation differ between healthy black and white subjects?
Absolute Event Rate: 1.76% vs 8.79%
p-value: p=<0.001
Endothelium-dependent vasodilatation is significantly impaired in healthy black subjects compared with white subjects, potentially contributing to increased risk of hypertension and vascular disease.
Perregaux et al. (2000) conducted a cross-sectional in Healthy subjects (n=52). Black ethnicity vs. White ethnicity was evaluated on Mean postischemic dilatation (p=<0.001). Healthy young black subjects had significantly impaired endothelium-dependent vasodilatation compared with matched white subjects (1.76% vs 8.79%, P<0.001).
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