A Comparative Study Of Liver Enzymes In The Individuals With Malarial Infection And Normal Healthy Individuals

Background: Obligate intracellular parasites cause malaria. The elimination of malaria has been hindered for centuries owing to the many pathophysiology and environmental factors involved. The sporozoites type of the malarial parasite has the potential to induce organ congestion, sinusoidal obstruction, and cellular inflammation in liver cells. The aforementioned alterations in hepatocytes have the potential to result in the release of parenchymal enzymes (transaminases) and membrane enzymes (alkaline phosphatase) from the liver into the bloodstream. Aim: The objective of the research was to investigate the impact of malaria parasitaemia on hepatic enzyme metabolites. Method: The study was conducted on total 100 individuals including 50 cases and 50 control group. The study is conducted in the tertiary care hospital attached with Rohilkhand medical college and hospital, Bareilly. The liver enzymes were analyzed by fully automated ERBA EM-360 biochemistry analyzer and malaria antigen card test (J. Mitra Kit) was used to detect malaria. Result: In our study we had observed statistically significant level of liver enzymes were increased in the individuals who has malarial infection and liver enzymes were normal in the normal individuals. Conclusion: The study found that people with malaria had significantly higher amounts of AST and ALT than the controls.