"The Role Of Neurotransmitters In Haloperidol-Induced Catalepsy: A Comprehensive Review Of The Current Understanding”

Background: The role of neurotransmitters in haloperidol-induced catalepsy has been a subject of extensive research. Haloperidol, a widely used antipsychotic medication, is known to induce motor disturbances resembling Parkinsonian symptoms, including catalepsy. Understanding the neurotransmitter mechanisms underlying this phenomenon is crucial for improving therapeutic strategies and minimizing side effects. Main Body: This comprehensive review explores the intricate interplay of neurotransmitters in haloperidol-induced catalepsy. Dopamine, a key player, exhibits dysregulation in response to haloperidol, impacting the nigrostriatal pathway. Additionally, serotonin, glutamate, and GABAergic systems contribute to the complex neurochemical alterations. The review synthesizes evidence from preclinical and clinical studies, shedding light on the dynamic interactions that culminate in cataleptic manifestations. Short Conclusion: In conclusion, unraveling the neurotransmitter intricacies in haloperidol-induced catalepsy is a critical step towards refining antipsychotic interventions. Insights gained from this review pave the way for targeted therapeutic approaches, aiming to mitigate motor side effects while preserving the efficacy of haloperidol in psychiatric treatment.