Social influences and cardiovascular risk factors as determinants of plasma fibrinogen concentration in a general population sample of middle aged men.
Key result
Low social activity scores at home were associated with higher plasma fibrinogen concentrations compared to high scores (mean difference 0.36 g/l; 95% CI 0.19-0.54) in non-smoking middle-aged men.
Why the study?
Do social influences and cardiovascular risk factors determine plasma fibrinogen concentration in middle-aged men?
Population
639 employed men aged 50 with no history of myocardial infarction or stroke, from a population sample in…
Comparison
Social influences and cardiovascular risk factors vs Different levels of social influences and risk…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Hypothesis-generating for social-CVD pathways via fibrinogen; prospective studies needed before any clinical consideration.
Key Points
- This research examines how social influences and cardiovascular risk factors affect fibrinogen concentration in middle-aged men.
- Cross sectional population study
- Involved 639 men aged 50 from a larger sample
- Measured fibrinogen concentration and assessed social factors such as household size and activity scores.
- Men with low home activity scores had higher fibrinogen levels (3.34 g/l) compared to those with high scores (3.02 g/l)
- Smoking significantly influenced fibrinogen levels; effects were mostly in non-smokers
- Occupational class and household size did not show a strong correlation with fibrinogen levels.
Study Design
Type
Cross-Sectional (n=639)
Multicenter
No
Structured PICO
Do social influences and cardiovascular risk factors determine plasma fibrinogen concentration in middle-aged men?
P
Population
639 employed men aged 50 with no history of myocardial infarction or stroke, from a population sample in Gothenburg, Sweden.
I
Intervention
Social influences (socioeconomic state, household size, social activity scores) and cardiovascular risk factors
C
Comparator
Different levels of social influences and risk factors
O
Outcome
Plasma fibrinogen concentrationsurrogate
Main Result
Effect estimate: Mean difference 0.36 g/l (95% CI 0.19 to 0.54)
Absolute Event Rate: 3.34% vs 3.02%
Psychosocial influences, specifically low social activity, are independently associated with higher plasma fibrinogen concentrations, suggesting a mechanism linking social factors to cardiovascular disease.
Cite This Study
Rosengren et al. (1990) conducted a cross-sectional in Cardiovascular risk factors (n=639). Social influences (activity scores, occupational class) vs. Different levels of social influences was evaluated on Fibrinogen concentration (Mean difference 0.36 g/l, 95% CI 0.19 to 0.54). Low social activity scores at home were associated with higher plasma fibrinogen concentrations compared to high scores (mean difference 0.36 g/l; 95% CI 0.19-0.54) in non-smoking middle-aged men.