Key result
Pomegranate peel extract plus vitamin E improves oxidative stress and antioxidative capacity in hemodialysis patients.
Why the study?
The study aimed to assess the effects of 8-week administration of pomegranate peel extract and vitamin E alone and in combination on oxidative stress and antioxidative capacity in hemodialysis patients.
Does pomegranate peel extract and vitamin E improve oxidative stress and antioxidative capacity in hemodialysis patients?
RCT (n=100)
Randomly divided
Does pomegranate peel extract and vitamin E improve oxidative stress and antioxidative capacity in hemodialysis patients?
Combination therapy with pomegranate peel extract and vitamin E significantly improves oxidative stress biomarkers in hemodialysis patients compared to either treatment alone or placebo.
Answers are grounded in this paper and cite their sources.
Supports adjunctive antioxidant use in hemodialysis; extends RCT evidence for pomegranate extract plus vitamin E on oxidative markers.
This study aimed to assess the effects of 8-week administration of pomegranate peel extract (PPE, ~180 mg ellagic acid) and vitamin E (Vit E, 400 IU) alone and in combination on oxidative stress (OS) and antioxidative capacity of hemodialysis (HD) patients. One hundred HD patients randomly divided in to 4 groups (control, PPE, Vit E, and PPE + Vit E). The changes of malondialdehyde, oxidized low-density lipoprotein, and myeloperoxidase in PPE + Vit E, PPE, and Vit E groups were significantly different compared to placebo group. The Changes of advanced oxidation protein products, superoxide dismutase, and oxygen radical absorbance capacity in PPE + Vit E group and changes of protein carbonyls in PPE and PPE + Vit E groups were significantly different compared to the other groups. As a result, consumption of PPE combined with Vit E was more effective than PPE or Vit E alone to ameliorate OS and enhance antioxidative capacity of HD patients.
No takes yet. Share an insight, caveat, or question.
Jafari et al. (2020) conducted an RCT in Hemodialysis (n=100). Pomegranate peel extract (PPE) and vitamin E (Vit E) vs. Placebo was evaluated on Oxidative stress and antioxidative capacity markers. Pomegranate peel extract combined with vitamin E (400 IU) for 8 weeks ameliorated oxidative stress and enhanced antioxidative capacity in hemodialysis patients.
Synapse has enriched 10 related papers. Consider them for comparative context: