Key result
Testosterone enhances Coxsackievirus B3 replication and drives mortality to 50% in male mice.
Why the study?
The impact of sex hormones on the intestinal replication and dissemination of Coxsackievirus B3 remains poorly understood.
Does testosterone enhance CVB3 shedding and dissemination in an oral inoculation mouse model?
Does testosterone enhance CVB3 shedding and dissemination in an oral inoculation mouse model?
Testosterone enhances the intestinal replication, shedding, and dissemination of Coxsackievirus B3 in a mouse model, highlighting the role of sex hormones in viral pathogenesis.
Answers are grounded in this paper and cite their sources.
Highlights sex hormone modulation of enteroviral replication in mice; leaves open human relevance and clinical implications.
Biological sex plays a significant role in the outcomes of various infections and diseases. The impact of sex hormones on the intestinal replication and dissemination of Coxsackievirus B3 remains poorly understood. Using an oral inoculation model, we found that testosterone enhances CVB3 shedding and dissemination in male and female mice. Further, testosterone can alter the immune response to CVB3. This work highlights the role of testosterone in CVB3 pathogenesis and suggests that sex hormones can impact the replication and dissemination of enteric viruses.
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Dhalech et al. (2022) studied Coxsackievirus B3 infection. Testosterone vs. Placebo was evaluated on Mortality at 14 days postinoculation in male mice (p=<0.01). Testosterone enhanced intestinal Coxsackievirus B3 replication and dissemination in both male and female mice, and increased mortality to 50% in male mice following oral inoculation.
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