Why the study?
Does testosterone promote myocarditis and CD4+ Th1 cell responses in Coxsackievirus B3-infected mice compared to estradiol?
Does testosterone promote myocarditis and CD4+ Th1 cell responses in Coxsackievirus B3-infected mice compared to estradiol?
Testosterone increases susceptibility to Coxsackievirus B3-induced myocarditis in mice by promoting gammadelta+ T-cell activation and a subsequent Th1 immune response.
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Testosterone may heighten viral myocarditis risk in males; leaves open human translation and gamma delta-targeted interventions.
Huber et al. (1999) studied this question.
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