Microbiota depletion, even with a single dose of one antibiotic, decreased coxsackievirus infection in mice, whereas poliovirus infection was unaffected.
Recent data indicate that intestinal bacteria promote intestinal infection of several enteric viruses. Here, we show that coxsackievirus, an enteric virus in the picornavirus family, also relies on microbiota for intestinal replication and pathogenesis. Relatively minor depletion of the microbiota was sufficient to decrease coxsackievirus infection, while poliovirus infection was unaffected. Surprisingly, a single dose of one antibiotic was sufficient to reduce coxsackievirus infection. Therefore, these data indicate that closely related viruses may differ with respect to their reliance on microbiota.
Robinson et al. (Mon,) conducted a other in Enteric virus infection. Microbiota depletion (antibiotic) was evaluated on Viral infection and replication. Microbiota depletion, even with a single dose of one antibiotic, decreased coxsackievirus infection in mice, whereas poliovirus infection was unaffected.