Formation of N‐(Deoxyguanosin‐8‐yl)aniline in the in vitro Reaction of N‐Acetoxyaniline with Deoxyguanosine and DNA

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The in vitro synthesis of the aniline–deoxyguanosine adduct 1 was achieved both with pure deoxyguanosine and with DNA. N Acetoxyaniline, a potential metabolite and possibly the ultimate carcinogen of aniline, was employed for this purpose. It was synthesized from phenylhydroxylamine and AcCN and reacts with deoxyguanosine to give 1 in 6% yield.