Key result
Four common murine AF models lack authentic reentrant circuits, poorly representing typical human AF.
Why the study?
To better characterize AF by profiling several commonly used murine AF models.
Population
Four murine models including C57BL/6 and Cardiac-LKB1 KO mice
Comparison
Carbachol plus burst pacing, Ang II infusion, TAC, and Cardiac-LKB1 KO models
Design
Preclinical experimental study
Authors
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Challenges reliance on common murine AF models for human translation; leaves open development of faithful preclinical platforms.
Four commonly used murine models of atrial fibrillation fail to replicate authentic human AF electrophysiology, suggesting they are poor representations of the disease.
Fu et al. (2021) studied Atrial fibrillation. Murine AF models vs. Control mice was evaluated on Presence of authentic atrial fibrillation (micro- or macro-reentrant circuits). Four commonly used murine atrial fibrillation models failed to exhibit authentic micro- or macro-reentrant circuits, suggesting they are poor representations of typical human AF.
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