Key result
Four common murine AF models lack authentic reentrant circuits typical of human AF.
Why the study?
Several commonly used murine atrial fibrillation models were profiled to establish a valid atrial fibrillation model in the laboratory.
Population
C57BL/6 mice and Cardiac-LKB1 KO mice
Comparison
Four commonly used murine AF models evaluated for authentic AF
Design
Preclinical laboratory study
Authors
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Raises caution for using common murine AF models in preclinical drug testing; leaves open need for human-relevant alternatives.
Commonly used murine models of atrial fibrillation do not accurately reflect human AF pathophysiology, raising caution for their use in preclinical anti-arrhythmic drug evaluation.
Fu et al. (2022) studied Atrial fibrillation. Murine AF models (Carbachol, TAC, Ang II, Cardiac-LKB1 KO) vs. Control/Sham was evaluated on Presence of authentic atrial fibrillation (reentrant circuits). Four commonly used murine atrial fibrillation models (carbachol, TAC, Ang II, and Cardiac-LKB1 KO) failed to exhibit authentic micro- or macro-reentrant atrial circuits typical of human AF.
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