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January 1, 2022Therapeutic Advances in Infectious DiseaseOpen Access

Norovirus disease among older adults

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Key result

Norovirus gastroenteritis disproportionately burdens adults over 65 with severe disease, higher hospitalization, and increased mortality.

Why the study?

Adults older than 65 years bear a significant proportion of the norovirus burden, with a disease course that is often more severe and protracted.

Population

Adults older than 65 years of age

Design

Narrative review

Authors

HTHelen TsaiAlbert Einstein College of MedicinePYPhilip S. YuneHofstra UniversityMRMana RaoLenox Hill Hospital

Discussion

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Implication

May prompt heightened vigilance in adults >65; leaves open need for interventional trials on prevention.

Structured PICO

P
Population
Adults older than 65 years of age with or at risk for norovirus infection

This narrative review summarizes the epidemiology, clinical manifestations, prevention, and management of norovirus disease, highlighting its significant burden and severity in adults older than 65 years.

Limitations

  • Lack of in vitro cell culture models for human norovirus complicates vaccine and treatment development
  • Uncertainty regarding optimal duration of isolation for patients at risk for prolonged viral shedding
  • Lack of FDA-approved treatments or vaccines for norovirus

Cite This Study

Tsai et al. (2022) conducted a review in Norovirus infection. Norovirus gastroenteritis disproportionately affects adults older than 65 years, who experience more severe and protracted disease courses, higher hospitalization rates, and increased mortality.

synapsesocial.com/papers/6a1706a0b13aec50ea6bc69fhttps://doi.org/10.1177/20499361221136760
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Progress toward norovirus vaccines: considerations for further development and implementation in potential target populations2015 · 47 citations
  2. 2What Is the Reservoir of Emergent Human Norovirus Strains?2015 · 86 citations
  3. 3Winter Vomiting Disease1969 · 348 citations
  4. 4Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology2015 · 392 citations
  5. 5Postinfectious Gastrointestinal Disorders Following Norovirus Outbreaks2012 · 74 citations