Why the study?
Does lidocaine or l-verapamil alter the upstroke phase of action potentials and conduction velocity in incompletely depolarized ventricular papillary muscle in the presence or absence of catecholamines?
Population
Incompletely depolarized ventricular papillary muscle perfused in a high K+ (16.7 mM) Tyrode's solution
Comparison
Lidocaine and l-verapamil in the presence or… vs Control conditions (absence of the specific drugs)
Design
Preclinical
Authors
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Hypothesis-generating for catecholamine-shifted antiarrhythmic sensitivity in depolarized tissue; requires validation in intact models.
Does lidocaine or l-verapamil alter the upstroke phase of action potentials and conduction velocity in incompletely depolarized ventricular papillary muscle in the presence or absence of catecholamines?
The dominant ionic channel responsible for slow conduction in high potassium media can be altered by extracellular catecholamine concentrations, shifting sensitivity from lidocaine to verapamil.
Arita et al. (1983) studied this question.
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