Why the study?
Do verapamil and its optical isomers suppress repetitive slow responses induced by electrical depolarization in canine ventricular myocardium?
Population
Canine ventricular papillary muscles excised from right and left ventricles of adult mongrel dogs
Comparison
Verapamil and its optical isomers vs Control conditions without drugs
Design
Preclinical
Authors
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Animal data on verapamil isomers should not guide therapy; leaves open mechanistic and translational questions in human arrhythmias.
Do verapamil and its optical isomers suppress repetitive slow responses induced by electrical depolarization in canine ventricular myocardium?
The l-isomer of verapamil is more potent than the d-isomer in suppressing repetitive slow responses in depolarized ventricular muscle, likely due to its ability to increase background outward potassium currents.
Saikawa et al. (1980) studied this question.
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