January 1, 1999Cellular Physiology and Biochemistry

Effect of Verapamil Enantiomers and Metabolites on Cardiac K+ Channels Expressed in Xenopus Oocytes

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Population

Xenopus oocytes expressing cardiac potassium channels

Design

Preclinical

Authors

SWS WaldeggerKlinik und Poliklinik für Kinder- und Jugendmedizin GNG. NiemeyerUniversity of Zurich KMKlaus MörikeCross-Cutting Cardiology

Discussion

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Implication

Verapamil's K+ channel blockade may influence cardiac electrophysiology; leaves open clinical relevance beyond Ca2+ inhibition in humans.

Structured PICO

Population

Xenopus oocytes expressing cardiac potassium channels (Kv1.1, Kv1.5, Kir2.1, HERG, and the IsK subunit of the IKs-channel complex)

Intervention

Verapamil, its optical enantiomers ((+)-verapamil and (-)-verapamil), and metabolites (norverapamil/D591, D703, D620, D617)

Outcome

Concentration-dependent block of potassium currents (IC50 values)surrogate

Verapamil and its active metabolites potently block cardiac delayed rectifier potassium channels, demonstrating that these channels are sensitive targets to calcium channel blockers.

Cite This Study

Waldegger et al. (1999) studied this question.

synapsesocial.com/papers/6a83a213a3cef8348e9966df https://doi.org/10.1159/000016304

View Full Paper

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Effect of Verapamil Enantiomers and Metabolites on Cardiac K+ Channels Expressed in Xenopus Oocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of Verapamil Enantiomers and Metabolites on Cardiac K+ Channels Expressed in Xenopus Oocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider