Why the study?
How do verapamil and diltiazem compare in their effects on calcium-dependent electrical activity in sheep cardiac Purkinje fibres?
Population
Sheep cardiac Purkinje fibres
Comparison
Verapamil and diltiazem vs Comparison between verapamil and diltiazem
Design
Preclinical
Authors
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Diltiazem's edge in this sheep model should not alter clinical calcium blocker selection; leaves open translation to human Purkinje fiber arrhythmias.
How do verapamil and diltiazem compare in their effects on calcium-dependent electrical activity in sheep cardiac Purkinje fibres?
Diltiazem and verapamil exhibit distinct electrophysiological effects on cardiac Purkinje fibers, with diltiazem being more effective at preventing oscillatory afterpotentials.
Amerini et al. (1985) studied this question.
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