Why the study?
Does diltiazem alter electrophysiologic properties in patients with impaired sinus or AV node function compared to control subjects?
Population
30 subjects with various degrees of sinus or AV node dysfunction, including patients with sick sinus…
Comparison
Diltiazem vs Control subjects
Design
Cohort
Authors
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Caution with diltiazem warranted in sick sinus syndrome; leaves open randomized confirmation of sinus and AV effects.
Does diltiazem alter electrophysiologic properties in patients with impaired sinus or AV node function compared to control subjects?
Diltiazem effectively depresses AV conduction, offering therapeutic value for AV nodal re-entrant arrhythmias, but is potentially hazardous in patients with sick sinus syndrome due to marked sinus inhibition.
Sugimoto et al. (1980) studied this question.
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