Key result
Diltiazem produced rate-dependent atrioventricular node depression, resulting in greater tachycardia slowing for rapid AVRTs (up to 40%) than for slower AVRTs (up to 18%, P<0.001).
Why the study?
Does diltiazem improve tachycardia slowing and termination in an experimental dog model of atrioventricular reentrant tachycardia?
Population
15 dogs with an experimental model of orthodromic atrioventricular reentrant tachycardia (AVRT)
Comparison
Diltiazem (two doses) vs Baseline (before diltiazem administration)
Design
Preclinical
Authors
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Diltiazem may exhibit rate-dependent AV nodal effects in canine AVRT; leaves open translation to human therapy.
Does diltiazem improve tachycardia slowing and termination in an experimental dog model of atrioventricular reentrant tachycardia?
p-value: p=<0.001
Diltiazem exhibits rate-dependent atrioventricular node depression, resulting in greater tachycardia slowing and termination during faster AVRTs.
Talajic et al. (1990) studied orthodromic atrioventricular reentrant tachycardia (AVRT) (n=15). Diltiazem vs. baseline was evaluated on degree of tachycardia slowing (p=<0.001). Diltiazem produced rate-dependent atrioventricular node depression, resulting in greater tachycardia slowing for rapid AVRTs (up to 40%) than for slower AVRTs (up to 18%, P<0.001).
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