Why the study?
Does intravenous diltiazem exert rate-dependent effects on atrioventricular nodal properties in patients undergoing electrophysiological studies?
Population
25 patients undergoing electrophysiological studies
Comparison
Intravenous diltiazem at three doses designed to… vs Control conditions
Design
Cohort
Authors
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May explain diltiazem efficacy in rapid SVTs; hypothesis-generating for rate-specific dosing in EP studies.
Does intravenous diltiazem exert rate-dependent effects on atrioventricular nodal properties in patients undergoing electrophysiological studies?
The depressant effects of diltiazem on human AV nodal function are highly dependent on atrial rate, with greater effects at shorter cycle lengths, which may contribute to its efficacy in supraventricular arrhythmias.
Talajic et al. (1992) studied this question.
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