Key result
In anesthetized dogs, diltiazem produced frequency-dependent increases in the AV node functional refractory period, with maximal increases of up to 154% during atrial fibrillation.
Why the study?
Does diltiazem affect the atrioventricular node in a frequency-dependent manner during experimental atrial fibrillation in anesthetized dogs?
Population
Anesthetized dogs with electrically induced atrial fibrillation
Comparison
Diltiazem (evaluated at doses 1, 2, and 3) vs Control
Design
Preclinical
Authors
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Diltiazem's frequency-dependent AV nodal effects may explain rate control in AF; leaves open translation from anesthetized dogs to humans.
Does diltiazem affect the atrioventricular node in a frequency-dependent manner during experimental atrial fibrillation in anesthetized dogs?
Diltiazem exhibits frequency-dependent effects on the AV node, which may account for its therapeutic efficacy in controlling ventricular rate during atrial fibrillation.
Talajic et al. (1989) studied Atrial fibrillation. Diltiazem vs. Control was evaluated on Atrioventricular node functional refractory period (AVFRP). In anesthetized dogs, diltiazem produced frequency-dependent increases in the AV node functional refractory period, with maximal increases of up to 154% during atrial fibrillation.