November 1, 1986Circulation
Frequency-dependent effects of calcium antagonists on atrioventricular conduction and refractoriness: demonstration and characterization in anesthetized dogs.
Why the study?
What are the frequency-dependent effects of verapamil, diltiazem, and nifedipine on atrioventricular conduction in vivo?
Population
Autonomically blocked dogs anesthetized with morphine and alpha-chloralose
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Suggests less use-dependent AV nodal effects with nifedipine in animals; leaves open translation to human frequency dependence.
Structured PICO
What are the frequency-dependent effects of verapamil, diltiazem, and nifedipine on atrioventricular conduction in vivo?
P
Population
Autonomically blocked dogs anesthetized with morphine and alpha-chloralose
I
Intervention
Verapamil, diltiazem, and nifedipine administered via loading and maintenance infusion techniques
O
Outcome
Changes in atrioventricular conduction and refractoriness (time constants for onset of and recovery from block)surrogate
Calcium-channel blockers exhibit frequency-dependent effects on atrioventricular conduction in vivo, with nifedipine showing faster recovery kinetics than verapamil or diltiazem.
Cite This Study
Talajic et al. (1986) studied this question.