Why the study?
Do equihypotensive doses of verapamil, diltiazem, and nifedipine produce different reflex chronotropic and inotropic responses in conscious dogs?
Do equihypotensive doses of verapamil, diltiazem, and nifedipine produce different reflex chronotropic and inotropic responses in conscious dogs?
Different calcium channel blockers exert varying degrees of autonomic reflex activation that modulate their direct chronotropic and inotropic effects, which may have important clinical implications.
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Distinct reflex responses to calcium channel blockers in dogs caution against direct extrapolation; leaves open class-specific effects in humans.
Nakaya et al. (1983) studied this question.
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