January 1, 1977Japanese Heart JournalOpen Access

Electrophysiologic Effects of Diltiazem, a New Slow Channel Inhibitor, on Canine Cardiac Fibers

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Why the study?

Does diltiazem alter the electrophysiologic properties of isolated canine cardiac fibers?

Population

Isolated perfused canine ventricular muscles and Purkinje fibers

Design

Preclinical

Authors

TSTetsunori SaikawaOita Medical Center YNYasuo NagamotoUniversity of Occupational and Environmental Health Japan MAMakoto AritaNational Institute of Genetics

Discussion

Member takes

Implication

Animal data on diltiazem's fiber effects remain hypothesis-generating; leaves open clinical antiarrhythmic translation.

Structured PICO

Does diltiazem alter the electrophysiologic properties of isolated canine cardiac fibers?

Population

Isolated perfused canine ventricular muscles and Purkinje fibers

Intervention

Diltiazem hydrochloride (CRD-401) at concentrations of 1 microg/ml and 5 microg/ml

Outcome

Electrophysiologic effects including action potential plateau, duration, maximum rate of rise (Vmax), resting potential, and contractile tensionsurrogate

Diltiazem demonstrates slow channel inhibitory effects and suppresses automaticity in canine cardiac fibers, suggesting potential antiarrhythmic properties.

Cite This Study

Saikawa et al. (1977) studied this question.

synapsesocial.com/papers/6a843f39cc8946f1d8c6c8ab https://doi.org/10.1536/ihj.18.235

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Electrophysiologic Effects of Diltiazem, a New Slow Channel Inhibitor, on Canine Cardiac Fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrophysiologic Effects of Diltiazem, a New Slow Channel Inhibitor, on Canine Cardiac Fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider