Key result
Diltiazem improves regional contraction and blunts MAPD shortening during reperfusion in ischemic dog hearts.
Why the study?
It was unclear whether diltiazem ameliorates myocardial contractile dysfunction by shortening monophasic action potential duration during myocardial ischemia.
Answers are grounded in this paper and cite their sources.
Diltiazem effects in canine ischemia remain hypothesis-generating; leaves open translation to human reperfusion injury.
The purpose of the following experiment was to determine whether amelioration of myocardial contractile dysfunction by diltiazem is mediated by shortening of monophasic action potential duration (MAPD) during myocardial ischemia in anesthetized dogs. Diltiazem improved regional contraction during reperfusion after 10-min occlusion. The shortening of MAPD and increase in [K+]e were blunted by treatment with diltiazem. These results suggest that shortening of action potential duration during myocardial ischemia is unlikely to be a reason for the amelioration of contractile dysfunction.
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Hamada et al. (2001) studied Myocardial ischemia. Diltiazem was evaluated on Regional contraction and monophasic action potential duration (MAPD). Diltiazem improved regional contraction during reperfusion and blunted the shortening of monophasic action potential duration in ischemic dog hearts.
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