Why the study?
Does diltiazem alter the electrophysiological and mechanical properties of smooth muscle cells in the canine basilar artery?
Population
Smooth muscle cells of the canine basilar artery
Comparison
Diltiazem (various concentrations, e.g., >10 M… vs Control conditions
Design
Preclinical
Authors
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May support mechanistic studies of cerebral vasodilation; leaves open translation to human basilar artery disorders.
Does diltiazem alter the electrophysiological and mechanical properties of smooth muscle cells in the canine basilar artery?
Diltiazem acts as a vasodilator on the canine basilar artery by suppressing calcium influx and the release of chemical transmitters from nerve terminals.
Fujiwara et al. (1982) studied this question.
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