Key result
Diltiazem inhibited calcium release induced by cationic depolarization from canine cardiac sarcoplasmic reticulum in a concentration-dependent manner, but had no effect on caffeine-induced release.
Why the study?
Does diltiazem inhibit calcium release from canine cardiac sarcoplasmic reticulum?
Population
Fragmented sarcoplasmic reticulum fraction (SR) prepared from the ventricle of canine heart
Comparison
Diltiazem (concentrations up to 10(-4) M) vs Control conditions (no diltiazem)
Design
Preclinical
Authors
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Should not yet inform clinical decisions; leaves open diltiazem's role in cardiac calcium handling in vivo.
Does diltiazem inhibit calcium release from canine cardiac sarcoplasmic reticulum?
Diltiazem inhibits depolarization-induced, but not caffeine-induced, calcium release from canine cardiac sarcoplasmic reticulum.
Hirata et al. (1983) studied this question. Diltiazem was evaluated on Ca2+ binding and Ca2+ release. Diltiazem inhibited calcium release induced by cationic depolarization from canine cardiac sarcoplasmic reticulum in a concentration-dependent manner, but had no effect on caffeine-induced release.
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