Key result
Atherogenic index of plasma linked to unstable carotid plaque risk peaking at ~0.10.
Why the study?
The atherogenic index of plasma is a marker of lipids and atherosclerosis, but its association with the risk of unstable carotid plaque remains unclear.
Is the atherogenic index of plasma associated with the risk of unstable carotid plaque?
Observational (n=10,732)
No
Is the atherogenic index of plasma associated with the risk of unstable carotid plaque?
Effect estimate: OR 1.24 (AIP <0.10); OR 0.78 (AIP ≥0.10) (95% CI 1.07-1.44; 0.70-0.88)
There is an inverted U-shaped association between the atherogenic index of plasma and unstable carotid plaque, suggesting its potential as a biomarker for risk assessment.
AIP may aid observational plaque risk stratification; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: The atherogenic index of plasma (AIP) is a marker of lipids and atherosclerosis. However, the association between the AIP and the risk of unstable carotid plaque remains unclear. METHODS: A total of 10,732 patients were enrolled. Carotid ultrasound was used to assess the stability of carotid plaque. The AIP was calculated using the formula AIP = log (TG/HDL-C). Logistic regression was used to investigate the association between the AIP and unstable carotid plaque. The nonlinear association between the AIP and unstable carotid plaque was analyzed using restricted cubic splines (RCSs), and a two-segment logistic regression risk model was constructed for both sides of the inflection point. RESULTS: Of the total number of patients, 7834 had stable carotid plaque and 2898 had unstable carotid plaque. Our findings demonstrated an inverted U-shaped association between the AIP and the risk of unstable carotid plaque (threshold = 0.10). When the AIP was <0.10, a significant positive association with unstable carotid plaque emerged (OR: 1.24, 95% CI: 1.07, 1.44); when the AIP was ≥0.10, it showed a significant negative association with unstable carotid plaque (OR: 0.78, 95% CI: 0.70, 0.88). CONCLUSIONS: Our findings demonstrated an inverted U-shaped association between the AIP and the risk of unstable carotid plaque, with a threshold of 0.10. The AIP could serve as a potential biomarker for unstable carotid plaque risk assessment.
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Huo et al. (2025) conducted an observational in Unstable carotid plaque (n=10,732). Atherogenic index of plasma (AIP) was evaluated on Unstable carotid plaque (OR 1.24 (AIP <0.10); OR 0.78 (AIP ≥0.10), 95% CI 1.07-1.44; 0.70-0.88). The atherogenic index of plasma demonstrated an inverted U-shaped association with unstable carotid plaque risk, with a threshold of 0.10 (OR 1.24 for <0.10; OR 0.78 for ≥0.10).
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