Key result
FMDV infection in pigs reduced circulating plasmacytoid dendritic cell numbers and IFN-alpha secretion by 48 hours post-infection, coinciding with peak viremia at 2-3 days.
Population
Pigs infected with multiple serotypes of Foot-and-mouth disease virus (FMDV)
Design
Preclinical
Follow-up
2-3 days post-infection
Authors
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Indicates potential FMDV immune evasion via pDC loss; hypothesis-generating for antiviral strategies in swine.
FMDV infection in pigs induces a transient decline in plasmacytoid dendritic cell numbers and function that coincides with lymphopenia and peak viremia, highlighting a mechanism of innate immune evasion.
Nfon et al. (2010) studied Foot-and-mouth disease virus (FMDV) infection. FMDV infection was evaluated on Serum IFN-alpha response, lymphopenia, and pDC numbers and function. FMDV infection in pigs reduced circulating plasmacytoid dendritic cell numbers and IFN-alpha secretion by 48 hours post-infection, coinciding with peak viremia at 2-3 days.
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