March 1, 2008Viral Immunology

Interferon-α Production by Swine Dendritic Cells Is Inhibited During Acute Infection with Foot-and-Mouth Disease Virus

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Population

Swine and their monocyte-derived dendritic cells and skin-derived dendritic cells

Comparison

Acute infection with Foot-and-Mouth Disease Virus vs Uninfected state (implied)

Design

Preclinical

Follow-up

Acute phase of infection

Authors

CNCharles NfonCanadian Food Inspection Agency GFGeoffrey S. FermanLeidos (United States)FTFelix N. TokaRoss University School of Veterinary Medicine

Discussion

Member takes

Implication

Suggests FMDV evasion via DC IFN-alpha inhibition in swine; hypothesis-generating for antiviral strategies pending other models.

Structured PICO

Population

Swine (in vivo model) and their monocyte-derived dendritic cells (MoDCs) and skin-derived dendritic cells (skin DCs)

Intervention

Acute infection with Foot-and-Mouth Disease Virus (FMDV)

Comparator

Uninfected state (implied)

Outcome

Production of IFN-alpha from MoDCs and skin DCssurrogate

FMDV evades the early immune response by inhibiting IFN-alpha production in dendritic cells without productively infecting them or impairing their antigen-presenting function.

Cite This Study

Nfon et al. (2008) studied this question.

synapsesocial.com/papers/6a6f89b175498292b708eaae https://doi.org/10.1089/vim.2007.0097

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Interferon-α Production by Swine Dendritic Cells Is Inhibited During Acute Infection with Foot-and-Mouth Disease Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interferon-α Production by Swine Dendritic Cells Is Inhibited During Acute Infection with Foot-and-Mouth Disease Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider