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December 3, 2009Journal of VirologyOpen Access

Interferon-Induced Protection against Foot-and-Mouth Disease Virus Infection Correlates with Enhanced Tissue-Specific Innate Immune Cell Infiltration and Interferon-Stimulated Gene Expression

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Population

28 circovirus-free Yorkshire gilts (ca. 40 to 60 lb)

Comparison

Ad5-vectors containing IFN-alpha, IFN-gamma, or… vs Ad5-Blue or PBS, inoculated 1 day prior to FMDV…

Design

Preclinical

Follow-up

7 days post-inoculation (6 days post-challenge)

Authors

FSFayna Díaz-San SegundoPlum Island Animal Disease CenterMMMauro Pires MoraesUniversidade Federal de ViçosaTSTeresa de los SantosPlum Island Animal Disease Center

Discussion

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Implication

Should not yet change FMDV management in swine; leaves open translation of IFN-based protection to veterinary practice.

Structured PICO

P
Population
28 circovirus-free Yorkshire gilts (ca. 40 to 60 lb)
I
Intervention
Ad5-vectors containing IFN-alpha (10^9 PFU), IFN-gamma (10^10 PFU), or a combination of both, inoculated 1 day prior to FMDV challenge
C
Comparator
Ad5-Blue (10^10 PFU) or PBS, inoculated 1 day prior to FMDV challenge
O
Outcome
Clinical signs, viremia, IFN-stimulated gene (ISG) induction, and infiltration by innate immune cells in blood, skin, and lymphoid tissuessurrogate

Adenovirus-delivered interferons protect swine against FMDV infection by modulating tissue-specific innate immune responses and upregulating antiviral genes.

Cite This Study

Segundo et al. (2009) studied this question.

synapsesocial.com/papers/6a9515543d7e4fca39b2cf37https://doi.org/10.1128/jvi.01874-09
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