In healthy young adults, 24-hour diastolic blood pressure variability was positively associated with inflammatory markers hs-CRP (p=0.001) and TNF-α (p=0.015), while systolic BPV showed no association.
Cohort (n=447)
Is short-term blood pressure variability associated with systemic inflammation in healthy young adults?
Diastolic blood pressure variability is positively associated with markers of low-grade inflammation (hs-CRP and TNF-α) in healthy young adults, suggesting it may serve as an early cardiovascular risk factor.
p-value: p=0.001
Blood pressure variability (BPV) is linked to cardiovascular disease (CVD) and systemic inflammation in adults, but its relevance in young, healthy populations remains unclear. This study examined the association between short-term BPV and inflammatory markers in 447 normotensive participants (mean age, 22.9 years) from the Georgia Stress and Heart (GSH) study, a cohort of Non-Hispanic Black and White individuals. Participants underwent 24 h ambulatory blood pressure monitoring and assessment of serum inflammatory markers, including hs-CRP, IFN-γ, IL-6, and TNF-α. BPV was quantified using average real variability (ARV), and generalized estimating equations (GEEs) were used to evaluate associations, adjusting for age, sex, race, and mean blood pressure. Diastolic BPV was significantly, positively associated with hs-CRP and TNF-α, whereas systolic BPV was not associated with any inflammatory marker. Specifically, 24 h diastolic BPV was positively associated with hs-CRP (p = 0.001) and TNF-α (p = 0.015), while daytime diastolic BPV was positively associated with hs-CRP (p = 0.002). Nighttime diastolic BPV was positively associated with both hs-CRP (p = 0.020) and TNF-α (p = 0.007). No significant associations were found between BPV and IL-6 or IFN-γ. These findings suggest diastolic BPV may be a marker of low-grade inflammation in healthy young adults and could represent an early cardiovascular risk factor that warrants longitudinal study.
Weeks et al. (Thu,) conducted a cohort in Healthy normotensive young adults (n=447). Short-term blood pressure variability was evaluated on Association between short-term BPV and inflammatory markers (hs-CRP, IFN-γ, IL-6, and TNF-α) (p=0.001). In healthy young adults, 24-hour diastolic blood pressure variability was positively associated with inflammatory markers hs-CRP (p=0.001) and TNF-α (p=0.015), while systolic BPV showed no association.